R T Dorr Selected Research

4- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- one

1/2012	Chemistry and pharmacology of imexon and related cyanoaziridines.
6/2001	Induction of mitochondrial changes in myeloma cells by imexon.
9/2000	Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon.

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R T Dorr Research Topics

Disease

10	Neoplasms (Cancer) 01/2012 - 02/2000
5	Multiple Myeloma 01/2012 - 09/2000
5	Melanoma (Melanoma, Malignant) 09/2001 - 02/2000
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2001 - 03/2001
3	Carcinogenesis 12/2000 - 06/2000
2	Skin Neoplasms (Skin Cancer) 12/2000 - 06/2000
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2012
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2012
1	Hematologic Neoplasms (Hematological Malignancy) 04/2003
1	Colonic Neoplasms (Colon Cancer) 09/2001
1	Ovarian Neoplasms (Ovarian Cancer) 08/2001
1	Acute Promyelocytic Leukemia 06/2001
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 03/2001
1	Lung Neoplasms (Lung Cancer) 03/2001
1	Breast Neoplasms (Breast Cancer) 03/2001
1	Sarcoma (Soft Tissue Sarcoma) 03/2001
1	Renal Cell Carcinoma (Grawitz Tumor) 03/2001
1	Leukemia 03/2001
1	Pancreatitis 01/2001
1	Actinic Keratosis 12/2000
1	Erythema 09/2000
1	Leukemia L1210 08/2000
1	Necrosis 05/2000
1	Prostatic Neoplasms (Prostate Cancer) 02/2000

Drug/Important Bio-Agent (IBA)

3	4- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- oneIBA 01/2012 - 09/2000
3	DNA (Deoxyribonucleic Acid)IBA 10/2001 - 03/2001
2	indoleIBA 10/2001 - 02/2000
2	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA 10/2001 - 02/2000
2	Masoprocol (Actinex)FDA Link 09/2001 - 04/2001
2	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 04/2001 - 12/2000
2	azonafideIBA 03/2001 - 08/2000
2	amonafideIBA 03/2001 - 08/2000
1	Gemcitabine FDA Link 01/2012
1	azimexonIBA 01/2012
1	Sulfhydryl Compounds (Thiols)IBA 01/2012
1	ciamexonIBA 01/2012
1	Melphalan (Alkeran)FDA LinkGeneric 04/2003
1	Etoposide (VP 16)FDA LinkGeneric 04/2003
1	etoposide phosphate (Etopophos)FDA Link 04/2003
1	Cytostatic AgentsIBA 10/2001
1	terameprocolIBA 09/2001
1	LignansIBA 09/2001
1	Paclitaxel (Taxol)FDA LinkGeneric 08/2001
1	PlatinumIBA 08/2001
1	taxaneIBA 08/2001
1	Bleomycin (Blenoxane)FDA LinkGeneric 08/2001
1	Carboplatin (JM8)FDA LinkGeneric 08/2001
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 04/2001
1	anthraceneIBA 03/2001
1	C 39 (C39)IBA 03/2001
1	AgarIBA 03/2001
1	2- (2'- (dimethylamino)ethyl)- 1,2- dihydro- 7- ethoxydibenz(de,h)isoquinoline- 1,3- dioneIBA 03/2001
1	Intercalating AgentsIBA 03/2001
1	2'- (2- hydroxyphenyl)- 2'- thiazoline- 4'- carboxylic acidIBA 01/2001
1	Amylases FDA Link 01/2001
1	Asparaginase (Elspar)FDA Link 01/2001
1	AsparagineIBA 01/2001
1	Biological ProductsIBA 01/2001
1	Lipase (Acid Lipase)FDA Link 01/2001
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2001
1	Ointments (Pastes)IBA 12/2000
1	SpermidineIBA 12/2000
1	A 7 (A-7)IBA 09/2000
1	TeaIBA 09/2000
1	Biomarkers (Surrogate Marker)IBA 06/2000
1	Complement System Proteins (Complement)IBA 06/2000
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 06/2000
1	Sunscreening Agents (Sunscreens)IBA 06/2000
1	CyclodextrinsIBA 05/2000
1	Acetates (Acetic Acid Esters)FDA Link 02/2000
1	Antineoplastic Agents (Antineoplastics)IBA 02/2000
1	cyclodrineIBA 02/2000
1	IndolequinonesIBA 02/2000

Therapy/Procedure

2	Chemoprevention 12/2000 - 06/2000
1	Stem Cell Transplantation 04/2003
1	Combination Drug Therapy (Combination Chemotherapy) 08/2001
1	Intramuscular Injections 01/2001
1	Topical Administration 12/2000